Rival gangs fight for pride and ego in a world destroyed by chemical warfare.

The year 2015 CE. The last era in which magecraft still thrived. The Chaldea Security Organization was founded to focus on preserving the continuation of human history. They observe a world which magecraft couldn't observe and science couldn't measure all to prevent the certain extinction of humanity. But one day, the future that Chaldea continued to observe disappears and humanity's extinction in 2017 becomes clear. Rather, it had already happened. The cause seems to be related to Fuyuki, a provincial town in Japan, in the year 2004 CE. There, an "unobservable region" that had not existed before appears. Based on the assumption that Fuyuki is the reason for humanity's extinction, Chaldea issues an order to explore, investigate, and possibly destroy this singularity – a quest for the Holy Grail, the Grand Order.

A sequel to Kwak Kyeong-taek's "Friend" in 2001, "Friends 2" is about three men who are gangsters based in the background of the year 1963 and 2010.